Cardiovascular Death and Testosterone


If you listen to most docs who are unfamiliar with TRT, they steer men away from testosterone because somewhere in their training they were told that testosterone leads to heart attacks.  To their credit, if what they were told was true, that would be the right thing to do. But is it? Is the information they were spoon-fed correct?

Up until 2015, there was no study that looked at Testosterone Replacement  Therapy Orange County (TRT) and cardiovascular death rates. Fortunately, Sharma et al., did a study with 83,010 veterans on TRT and looked at cardiovascular outcomes including heart attacks and strokes. The aim of the study was to look at what happened to outcomes when testosterone (T) levels were normalized.

The veterans were broken into three groups, one received no treatment, one received treatment off/on (no normalization of T levels), and the other group received TRT with normalization of T levels. The median age of participants was 66 years and time of follow-up was 6.2 years.

The end data showed that the group who had testosterone levels normalized were 56% less likely to die from all causes compared to the non-treatment group. They were 36% less likely to have a stroke and 24% less likely to have a heart attack.  There was no difference in heart attacks and stroke rates among the partial treatment group and the non-treatment group.

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